| Otsego to Southern Pines (North Carolina) | 1,020.30 mi (1,642.01 km) |
| Otsego to Southfield (Michigan) | 550.33 mi (885.67 km) |
| Otsego to Southgate (Michigan) | 560.76 mi (902.46 km) |
| Otsego to Southlake (Texas) | 871.20 mi (1,402.07 km) |
| Otsego to Spanaway (Washington) | 1,375.84 mi (2,214.21 km) |
| Otsego to Spanish Fork (Utah) | 979.45 mi (1,576.27 km) |
| Otsego to Spanish Lake (Missouri) | 480.49 mi (773.27 km) |
| Otsego to Spanish Springs (Nevada) | 1,376.35 mi (2,215.02 km) |
| Otsego to Sparks (Nevada) | 1,381.03 mi (2,222.56 km) |
| Otsego to Spartanburg (South Carolina) | 941.70 mi (1,515.52 km) |
| Otsego to Spearfish (South Dakota) | 501.69 mi (807.39 km) |
| Otsego to Speedway (Indiana) | 532.34 mi (856.72 km) |
| Otsego to Spencer (Iowa) | 164.94 mi (265.44 km) |
| Otsego to Spokane (Washington) | 1,140.71 mi (1,835.79 km) |
| Otsego to Spokane Valley (Washington) | 1,131.48 mi (1,820.94 km) |
