| Paducah to Elyria (Ohio) | 459.03 mi (738.74 km) |
| Paducah to Emeryville (California) | 1,836.33 mi (2,955.29 km) |
| Paducah to Emmaus (Pennsylvania) | 746.34 mi (1,201.12 km) |
| Paducah to Emporia (Kansas) | 422.50 mi (679.95 km) |
| Paducah to Encinitas (California) | 1,635.78 mi (2,632.53 km) |
| Paducah to Endicott (New York) | 753.50 mi (1,212.64 km) |
| Paducah to Endwell (New York) | 756.03 mi (1,216.72 km) |
| Paducah to Englewood (Colorado) | 902.18 mi (1,451.92 km) |
| Paducah to Englewood (Florida) | 788.65 mi (1,269.20 km) |
| Paducah to Englewood (New Jersey) | 829.76 mi (1,335.38 km) |
| Paducah to Englewood (Ohio) | 303.73 mi (488.80 km) |
| Paducah to Enid (Oklahoma) | 512.69 mi (825.10 km) |
| Paducah to Ennis (Texas) | 559.61 mi (900.60 km) |
| Paducah to Ensley (Florida) | 459.01 mi (738.70 km) |
| Paducah to Enterprise (Alabama) | 427.78 mi (688.44 km) |
