| Paducah to Enterprise (Nevada) | 1,472.75 mi (2,370.16 km) |
| Paducah to Enumclaw (Washington) | 1,828.95 mi (2,943.40 km) |
| Paducah to Ephrata (Pennsylvania) | 705.48 mi (1,135.36 km) |
| Paducah to Erie (Colorado) | 907.90 mi (1,461.13 km) |
| Paducah to Erie (Pennsylvania) | 573.75 mi (923.37 km) |
| Paducah to Erlanger (Kentucky) | 258.25 mi (415.62 km) |
| Paducah to Escanaba (Michigan) | 604.85 mi (973.40 km) |
| Paducah to Escondido (California) | 1,623.57 mi (2,612.89 km) |
| Paducah to Española (New Mexico) | 968.75 mi (1,559.06 km) |
| Paducah to Essex (Maryland) | 679.61 mi (1,093.73 km) |
| Paducah to Essex Junction (Vermont) | 958.23 mi (1,542.13 km) |
| Paducah to Estelle (Louisiana) | 506.30 mi (814.81 km) |
| Paducah to Estero (Florida) | 837.66 mi (1,348.08 km) |
| Paducah to Euclid (Ohio) | 492.14 mi (792.02 km) |
| Paducah to Eufaula (Alabama) | 408.24 mi (657.01 km) |
