| Paducah to Oskaloosa (Iowa) | 361.67 mi (582.04 km) |
| Paducah to Oswego (Illinois) | 319.10 mi (513.54 km) |
| Paducah to Oswego (New York) | 776.09 mi (1,249.00 km) |
| Paducah to Otsego (Minnesota) | 622.24 mi (1,001.40 km) |
| Paducah to Ottawa (Illinois) | 296.18 mi (476.66 km) |
| Paducah to Ottawa (Kansas) | 376.24 mi (605.50 km) |
| Paducah to Ottumwa (Iowa) | 339.70 mi (546.69 km) |
| Paducah to Overland (Missouri) | 146.49 mi (235.75 km) |
| Paducah to Overland Park (Kansas) | 352.13 mi (566.69 km) |
| Paducah to Overlea (Maryland) | 676.50 mi (1,088.72 km) |
| Paducah to Oviedo (Florida) | 724.11 mi (1,165.35 km) |
| Paducah to Owasso (Oklahoma) | 401.81 mi (646.65 km) |
| Paducah to Owatonna (Minnesota) | 541.26 mi (871.08 km) |
| Paducah to Owensboro (Kentucky) | 96.28 mi (154.94 km) |
| Paducah to Owings Mills (Maryland) | 662.67 mi (1,066.46 km) |
