| Paducah to Santa Rosa (California) | 1,852.50 mi (2,981.31 km) |
| Paducah to Santaquin (Utah) | 1,263.69 mi (2,033.72 km) |
| Paducah to Santee (California) | 1,624.73 mi (2,614.76 km) |
| Paducah to Sapulpa (Oklahoma) | 420.25 mi (676.33 km) |
| Paducah to Saraland (Alabama) | 431.11 mi (693.80 km) |
| Paducah to Sarasota (Florida) | 760.72 mi (1,224.26 km) |
| Paducah to Sarasota Springs (Florida) | 764.45 mi (1,230.26 km) |
| Paducah to Saratoga (California) | 1,828.29 mi (2,942.35 km) |
| Paducah to Saratoga Springs (New York) | 886.76 mi (1,427.10 km) |
| Paducah to Saratoga Springs (Utah) | 1,271.10 mi (2,045.63 km) |
| Paducah to Sartell (Minnesota) | 657.21 mi (1,057.68 km) |
| Paducah to Satellite Beach (Florida) | 771.66 mi (1,241.87 km) |
| Paducah to Sauk Rapids (Minnesota) | 654.44 mi (1,053.21 km) |
| Paducah to Sault Ste. Marie (Michigan) | 686.18 mi (1,104.29 km) |
| Paducah to Savage (Minnesota) | 585.01 mi (941.48 km) |
