| Paducah to Scottsboro (Alabama) | 221.88 mi (357.09 km) |
| Paducah to Scottsdale (Arizona) | 1,325.42 mi (2,133.06 km) |
| Paducah to Scranton (Pennsylvania) | 755.35 mi (1,215.62 km) |
| Paducah to Seabrook (Maryland) | 654.81 mi (1,053.82 km) |
| Paducah to Seabrook (Texas) | 635.15 mi (1,022.17 km) |
| Paducah to Seaford (New York) | 850.85 mi (1,369.31 km) |
| Paducah to Seagoville (Texas) | 541.77 mi (871.89 km) |
| Paducah to Seal Beach (California) | 1,666.12 mi (2,681.36 km) |
| Paducah to Searcy (Arkansas) | 213.78 mi (344.05 km) |
| Paducah to Seaside (California) | 1,825.19 mi (2,937.36 km) |
| Paducah to SeaTac (Washington) | 1,846.19 mi (2,971.16 km) |
| Paducah to Seattle (Washington) | 1,849.62 mi (2,976.68 km) |
| Paducah to Sebastian (Florida) | 798.30 mi (1,284.75 km) |
| Paducah to Sebring (Florida) | 784.17 mi (1,262.00 km) |
| Paducah to Secaucus (New Jersey) | 823.28 mi (1,324.93 km) |
