| Paducah to Seymour (Tennessee) | 283.18 mi (455.74 km) |
| Paducah to Shady Hills (Florida) | 695.41 mi (1,119.15 km) |
| Paducah to Shafter (California) | 1,698.34 mi (2,733.21 km) |
| Paducah to Shaker Heights (Ohio) | 486.07 mi (782.26 km) |
| Paducah to Shakopee (Minnesota) | 588.75 mi (947.51 km) |
| Paducah to Sharon (Pennsylvania) | 522.27 mi (840.51 km) |
| Paducah to Sharonville (Ohio) | 276.18 mi (444.47 km) |
| Paducah to Shasta Lake (California) | 1,820.27 mi (2,929.44 km) |
| Paducah to Shawnee (Kansas) | 361.20 mi (581.30 km) |
| Paducah to Shawnee (Oklahoma) | 478.62 mi (770.26 km) |
| Paducah to Sheboygan (Wisconsin) | 463.28 mi (745.58 km) |
| Paducah to Shelby (North Carolina) | 414.45 mi (667.00 km) |
| Paducah to Shelbyville (Indiana) | 230.43 mi (370.85 km) |
| Paducah to Shelbyville (Kentucky) | 202.62 mi (326.09 km) |
| Paducah to Shelbyville (Tennessee) | 163.43 mi (263.01 km) |
