| Paducah to Southern Pines (North Carolina) | 531.47 mi (855.32 km) |
| Paducah to Southfield (Michigan) | 470.11 mi (756.57 km) |
| Paducah to Southgate (Michigan) | 457.54 mi (736.34 km) |
| Paducah to Southlake (Texas) | 558.77 mi (899.25 km) |
| Paducah to Spanaway (Washington) | 1,847.77 mi (2,973.70 km) |
| Paducah to Spanish Fork (Utah) | 1,255.90 mi (2,021.18 km) |
| Paducah to Spanish Lake (Missouri) | 146.08 mi (235.09 km) |
| Paducah to Spanish Springs (Nevada) | 1,681.86 mi (2,706.69 km) |
| Paducah to Sparks (Nevada) | 1,684.74 mi (2,711.32 km) |
| Paducah to Spartanburg (South Carolina) | 403.14 mi (648.80 km) |
| Paducah to Spearfish (South Dakota) | 942.56 mi (1,516.91 km) |
| Paducah to Speedway (Indiana) | 228.46 mi (367.66 km) |
| Paducah to Spencer (Iowa) | 542.35 mi (872.83 km) |
| Paducah to Spokane (Washington) | 1,628.91 mi (2,621.47 km) |
| Paducah to Spokane Valley (Washington) | 1,619.96 mi (2,607.07 km) |
