| Paducah to Storm Lake (Iowa) | 518.30 mi (834.12 km) |
| Paducah to Storrs (Connecticut) | 932.11 mi (1,500.08 km) |
| Paducah to Stoughton (Wisconsin) | 405.53 mi (652.64 km) |
| Paducah to Stow (Ohio) | 479.09 mi (771.03 km) |
| Paducah to Streamwood (Illinois) | 342.90 mi (551.84 km) |
| Paducah to Streator (Illinois) | 280.24 mi (451.00 km) |
| Paducah to Streetsboro (Ohio) | 485.36 mi (781.11 km) |
| Paducah to Strongsville (Ohio) | 467.70 mi (752.68 km) |
| Paducah to Stuart (Florida) | 840.02 mi (1,351.89 km) |
| Paducah to Stuarts Draft (Virginia) | 530.19 mi (853.27 km) |
| Paducah to Sturgis (Michigan) | 369.17 mi (594.13 km) |
| Paducah to Suamico (Wisconsin) | 523.50 mi (842.50 km) |
| Paducah to Sudley (Virginia) | 618.60 mi (995.53 km) |
| Paducah to Suffern (New York) | 825.07 mi (1,327.83 km) |
| Paducah to Suffolk (Virginia) | 663.48 mi (1,067.77 km) |
