| Paducah to Superior (Colorado) | 913.18 mi (1,469.62 km) |
| Paducah to Superior (Wisconsin) | 687.82 mi (1,106.94 km) |
| Paducah to Surprise (Arizona) | 1,357.82 mi (2,185.19 km) |
| Paducah to Susanville (California) | 1,728.68 mi (2,782.05 km) |
| Paducah to Sussex (Wisconsin) | 419.54 mi (675.18 km) |
| Paducah to Suwanee (Georgia) | 331.11 mi (532.87 km) |
| Paducah to Swansea (Illinois) | 125.76 mi (202.39 km) |
| Paducah to Sweetwater (Florida) | 919.06 mi (1,479.08 km) |
| Paducah to Sweetwater (Texas) | 738.85 mi (1,189.06 km) |
| Paducah to Sycamore (Illinois) | 340.26 mi (547.60 km) |
| Paducah to Sylacauga (Alabama) | 300.80 mi (484.09 km) |
| Paducah to Sylvania (Ohio) | 414.77 mi (667.51 km) |
| Paducah to Syosset (New York) | 852.55 mi (1,372.04 km) |
| Paducah to Syracuse (New York) | 777.94 mi (1,251.98 km) |
| Paducah to Syracuse (Utah) | 1,282.54 mi (2,064.06 km) |
