| Palermo to Santeramo in Colle | 259.57 mi (417.74 km) |
| Palermo to Santo Stefano di Magra | 454.54 mi (731.51 km) |
| Palermo to Santo Stino di Livenza | 527.47 mi (848.88 km) |
| Palermo to Sarezzo | 545.26 mi (877.51 km) |
| Palermo to Sarno | 198.26 mi (319.08 km) |
| Palermo to Saronno | 564.34 mi (908.22 km) |
| Palermo to Sarzana | 450.54 mi (725.08 km) |
| Palermo to Sassari | 313.35 mi (504.29 km) |
| Palermo to Sasso Marconi | 447.79 mi (720.65 km) |
| Palermo to Sassuolo | 464.26 mi (747.15 km) |
| Palermo to Sava | 274.78 mi (442.22 km) |
| Palermo to Saviano | 203.09 mi (326.84 km) |
| Palermo to Savigliano | 540.05 mi (869.13 km) |
| Palermo to Savignano sul Panaro | 456.20 mi (734.18 km) |
| Palermo to Savignano sul Rubicone | 415.71 mi (669.02 km) |
