| Palos de la Frontera to Savignano sul Rubicone | 1,112.94 mi (1,791.11 km) |
| Palos de la Frontera to Savona | 939.30 mi (1,511.66 km) |
| Palos de la Frontera to Scafati | 1,172.65 mi (1,887.20 km) |
| Palos de la Frontera to Scalea | 1,236.33 mi (1,989.68 km) |
| Palos de la Frontera to Scandiano | 1,046.49 mi (1,684.16 km) |
| Palos de la Frontera to Scandicci | 1,048.79 mi (1,687.87 km) |
| Palos de la Frontera to Schio | 1,107.91 mi (1,783.00 km) |
| Palos de la Frontera to Sciacca | 1,095.42 mi (1,762.91 km) |
| Palos de la Frontera to Scicli | 1,189.37 mi (1,914.10 km) |
| Palos de la Frontera to Scordia | 1,193.04 mi (1,920.01 km) |
| Palos de la Frontera to Scorze | 1,136.98 mi (1,829.80 km) |
| Palos de la Frontera to Sedico | 1,152.26 mi (1,854.39 km) |
| Palos de la Frontera to Sedriano | 998.10 mi (1,606.29 km) |
| Palos de la Frontera to Segni | 1,103.05 mi (1,775.19 km) |
| Palos de la Frontera to Segrate | 1,012.25 mi (1,629.06 km) |
