| Palos de la Frontera to Sestu | 877.77 mi (1,412.64 km) |
| Palos de la Frontera to Settimo Torinese | 935.50 mi (1,505.54 km) |
| Palos de la Frontera to Seveso | 1,010.72 mi (1,626.60 km) |
| Palos de la Frontera to Sezze | 1,103.55 mi (1,776.00 km) |
| Palos de la Frontera to Siano | 1,181.76 mi (1,901.86 km) |
| Palos de la Frontera to Siena | 1,046.02 mi (1,683.41 km) |
| Palos de la Frontera to Signa | 1,045.25 mi (1,682.16 km) |
| Palos de la Frontera to Silea | 1,147.59 mi (1,846.87 km) |
| Palos de la Frontera to Silvi Paese | 1,169.37 mi (1,881.92 km) |
| Palos de la Frontera to Sinalunga | 1,063.30 mi (1,711.21 km) |
| Palos de la Frontera to Siniscola | 920.00 mi (1,480.60 km) |
| Palos de la Frontera to Sinnai | 883.72 mi (1,422.21 km) |
| Palos de la Frontera to Siracusa | 1,218.85 mi (1,961.55 km) |
| Palos de la Frontera to Solaro | 1,007.50 mi (1,621.42 km) |
| Palos de la Frontera to Soliera | 1,061.13 mi (1,707.72 km) |
