| Penafiel to Sacile | 1,087.28 mi (1,749.81 km) |
| Penafiel to Sala Consilina | 1,246.47 mi (2,006.00 km) |
| Penafiel to Salemi | 1,145.01 mi (1,842.71 km) |
| Penafiel to Salerno | 1,199.68 mi (1,930.70 km) |
| Penafiel to Salo | 989.47 mi (1,592.39 km) |
| Penafiel to Salsomaggiore Terme | 953.53 mi (1,534.56 km) |
| Penafiel to Saluzzo | 831.17 mi (1,337.64 km) |
| Penafiel to Salzano | 1,064.06 mi (1,712.44 km) |
| Penafiel to Samarate | 907.08 mi (1,459.81 km) |
| Penafiel to San Benedetto del Tronto | 1,139.84 mi (1,834.40 km) |
| Penafiel to San Biagio di Callalta | 1,078.39 mi (1,735.50 km) |
| Penafiel to San Bonifacio | 1,022.72 mi (1,645.91 km) |
| Penafiel to San Casciano in Val di Pesa | 1,004.82 mi (1,617.09 km) |
| Penafiel to San Cataldo | 1,213.71 mi (1,953.28 km) |
| Penafiel to San Cesareo | 1,088.94 mi (1,752.48 km) |
