| Penafiel to Selargius | 928.42 mi (1,494.15 km) |
| Penafiel to Selvazzano Dentro | 1,046.49 mi (1,684.16 km) |
| Penafiel to Senago | 923.03 mi (1,485.47 km) |
| Penafiel to Senigallia | 1,106.44 mi (1,780.64 km) |
| Penafiel to Seravezza | 959.14 mi (1,543.59 km) |
| Penafiel to Seregno | 927.20 mi (1,492.19 km) |
| Penafiel to Seriate | 952.11 mi (1,532.28 km) |
| Penafiel to Sermoneta | 1,100.07 mi (1,770.40 km) |
| Penafiel to Serramanna | 913.27 mi (1,469.76 km) |
| Penafiel to Serravalle Pistoiese | 988.32 mi (1,590.55 km) |
| Penafiel to Sessa Aurunca | 1,151.50 mi (1,853.15 km) |
| Penafiel to Sesto Calende | 901.99 mi (1,451.61 km) |
| Penafiel to Sesto Fiorentino | 1,006.23 mi (1,619.37 km) |
| Penafiel to Sesto San Giovanni | 926.98 mi (1,491.83 km) |
| Penafiel to Sestri Levante | 919.75 mi (1,480.20 km) |
