| Penafiel to Sestu | 924.09 mi (1,487.19 km) |
| Penafiel to Settimo Torinese | 851.40 mi (1,370.20 km) |
| Penafiel to Seveso | 924.16 mi (1,487.29 km) |
| Penafiel to Sezze | 1,104.72 mi (1,777.88 km) |
| Penafiel to Siano | 1,194.97 mi (1,923.12 km) |
| Penafiel to Siena | 1,011.18 mi (1,627.34 km) |
| Penafiel to Signa | 1,001.03 mi (1,611.01 km) |
| Penafiel to Silea | 1,073.99 mi (1,728.42 km) |
| Penafiel to Silvi Paese | 1,152.76 mi (1,855.18 km) |
| Penafiel to Sinalunga | 1,031.25 mi (1,659.63 km) |
| Penafiel to Siniscola | 938.49 mi (1,510.35 km) |
| Penafiel to Sinnai | 929.82 mi (1,496.40 km) |
| Penafiel to Siracusa | 1,290.86 mi (2,077.43 km) |
| Penafiel to Solaro | 921.19 mi (1,482.52 km) |
| Penafiel to Soliera | 998.68 mi (1,607.21 km) |
