| Penafiel to Ede | 996.33 mi (1,603.44 km) |
| Penafiel to Eemnes | 993.24 mi (1,598.47 km) |
| Penafiel to Eerbeek | 1,011.28 mi (1,627.49 km) |
| Penafiel to Eersel | 952.53 mi (1,532.95 km) |
| Penafiel to Eijsden | 939.65 mi (1,512.22 km) |
| Penafiel to Eindhoven | 961.72 mi (1,547.74 km) |
| Penafiel to Elburg | 1,021.00 mi (1,643.15 km) |
| Penafiel to Emmeloord | 1,030.58 mi (1,658.56 km) |
| Penafiel to Emmen | 1,068.89 mi (1,720.21 km) |
| Penafiel to Enkhuizen | 1,016.85 mi (1,636.46 km) |
| Penafiel to Enschede | 1,042.90 mi (1,678.38 km) |
| Penafiel to Epe | 1,020.30 mi (1,642.02 km) |
| Penafiel to Ermelo | 1,006.73 mi (1,620.17 km) |
| Penafiel to Etten-Leur | 941.36 mi (1,514.98 km) |
| Penafiel to Franeker | 1,048.53 mi (1,687.45 km) |
