| Philadelphia to Enterprise (Nevada) | 2,181.64 mi (3,511.01 km) |
| Philadelphia to Enumclaw (Washington) | 2,359.37 mi (3,797.04 km) |
| Philadelphia to Ephrata (Pennsylvania) | 56.64 mi (91.15 km) |
| Philadelphia to Erie (Colorado) | 1,574.79 mi (2,534.37 km) |
| Philadelphia to Erie (Pennsylvania) | 295.65 mi (475.80 km) |
| Philadelphia to Erlanger (Kentucky) | 508.32 mi (818.06 km) |
| Philadelphia to Escanaba (Michigan) | 722.52 mi (1,162.78 km) |
| Philadelphia to Escondido (California) | 2,352.78 mi (3,786.44 km) |
| Philadelphia to Española (New Mexico) | 1,697.96 mi (2,732.60 km) |
| Philadelphia to Essex (Maryland) | 85.09 mi (136.94 km) |
| Philadelphia to Essex Junction (Vermont) | 326.45 mi (525.38 km) |
| Philadelphia to Estelle (Louisiana) | 1,098.21 mi (1,767.40 km) |
| Philadelphia to Estero (Florida) | 1,013.41 mi (1,630.93 km) |
| Philadelphia to Euclid (Ohio) | 351.30 mi (565.36 km) |
| Philadelphia to Eufaula (Alabama) | 790.71 mi (1,272.52 km) |
