| Port Huron to Sacile | 4,386.66 mi (7,059.64 km) |
| Port Huron to Sala Consilina | 4,743.70 mi (7,634.25 km) |
| Port Huron to Salemi | 4,738.21 mi (7,625.42 km) |
| Port Huron to Salerno | 4,697.15 mi (7,559.33 km) |
| Port Huron to Salo | 4,323.60 mi (6,958.17 km) |
| Port Huron to Salsomaggiore Terme | 4,332.26 mi (6,972.10 km) |
| Port Huron to Saluzzo | 4,237.64 mi (6,819.82 km) |
| Port Huron to Salzano | 4,388.97 mi (7,063.36 km) |
| Port Huron to Samarate | 4,252.96 mi (6,844.48 km) |
| Port Huron to San Benedetto del Tronto | 4,565.23 mi (7,347.03 km) |
| Port Huron to San Biagio di Callalta | 4,393.24 mi (7,070.24 km) |
| Port Huron to San Bonifacio | 4,361.31 mi (7,018.85 km) |
| Port Huron to San Casciano in Val di Pesa | 4,427.17 mi (7,124.84 km) |
| Port Huron to San Cataldo | 4,803.09 mi (7,729.83 km) |
| Port Huron to San Cesareo | 4,568.60 mi (7,352.45 km) |
