| Port Huron to Savignano sul Rubicone | 4,458.37 mi (7,175.06 km) |
| Port Huron to Savona | 4,291.17 mi (6,905.98 km) |
| Port Huron to Scafati | 4,684.39 mi (7,538.80 km) |
| Port Huron to Scalea | 4,777.31 mi (7,688.34 km) |
| Port Huron to Scandiano | 4,369.57 mi (7,032.15 km) |
| Port Huron to Scandicci | 4,423.38 mi (7,118.74 km) |
| Port Huron to Schio | 4,351.84 mi (7,003.61 km) |
| Port Huron to Sciacca | 4,763.82 mi (7,666.62 km) |
| Port Huron to Scicli | 4,864.04 mi (7,827.91 km) |
| Port Huron to Scordia | 4,847.93 mi (7,801.99 km) |
| Port Huron to Scorze | 4,387.12 mi (7,060.38 km) |
| Port Huron to Sedico | 4,365.01 mi (7,024.81 km) |
| Port Huron to Sedriano | 4,265.46 mi (6,864.60 km) |
| Port Huron to Segni | 4,583.07 mi (7,375.74 km) |
| Port Huron to Segrate | 4,278.41 mi (6,885.44 km) |
