| Portalegre to Sacile | 1,107.69 mi (1,782.65 km) |
| Portalegre to Sala Consilina | 1,219.61 mi (1,962.77 km) |
| Portalegre to Salemi | 1,094.77 mi (1,761.87 km) |
| Portalegre to Salerno | 1,174.44 mi (1,890.07 km) |
| Portalegre to Salo | 1,009.76 mi (1,625.05 km) |
| Portalegre to Salsomaggiore Terme | 967.30 mi (1,556.72 km) |
| Portalegre to Saluzzo | 847.85 mi (1,364.49 km) |
| Portalegre to Salzano | 1,081.29 mi (1,740.16 km) |
| Portalegre to Samarate | 930.99 mi (1,498.28 km) |
| Portalegre to San Benedetto del Tronto | 1,133.21 mi (1,823.72 km) |
| Portalegre to San Biagio di Callalta | 1,096.57 mi (1,764.77 km) |
| Portalegre to San Bonifacio | 1,039.97 mi (1,673.67 km) |
| Portalegre to San Casciano in Val di Pesa | 1,005.94 mi (1,618.90 km) |
| Portalegre to San Cataldo | 1,162.92 mi (1,871.55 km) |
| Portalegre to San Cesareo | 1,072.50 mi (1,726.02 km) |
