| Portalegre to Santa Venerina | 1,221.37 mi (1,965.61 km) |
| Portalegre to Santeramo in Colle | 1,278.93 mi (2,058.24 km) |
| Portalegre to Santo Stefano di Magra | 951.96 mi (1,532.03 km) |
| Portalegre to Santo Stino di Livenza | 1,111.45 mi (1,788.71 km) |
| Portalegre to Sarezzo | 995.72 mi (1,602.46 km) |
| Portalegre to Sarno | 1,166.57 mi (1,877.41 km) |
| Portalegre to Saronno | 942.59 mi (1,516.95 km) |
| Portalegre to Sarzana | 953.27 mi (1,534.14 km) |
| Portalegre to Sassari | 849.71 mi (1,367.48 km) |
| Portalegre to Sasso Marconi | 1,020.00 mi (1,641.52 km) |
| Portalegre to Sassuolo | 1,000.38 mi (1,609.96 km) |
| Portalegre to Sava | 1,322.77 mi (2,128.80 km) |
| Portalegre to Saviano | 1,161.11 mi (1,868.63 km) |
| Portalegre to Savigliano | 854.54 mi (1,375.25 km) |
| Portalegre to Savignano sul Panaro | 1,011.01 mi (1,627.06 km) |
