| Portalegre to Savignano sul Rubicone | 1,070.67 mi (1,723.07 km) |
| Portalegre to Savona | 886.47 mi (1,426.64 km) |
| Portalegre to Scafati | 1,161.96 mi (1,869.99 km) |
| Portalegre to Scalea | 1,233.60 mi (1,985.28 km) |
| Portalegre to Scandiano | 996.46 mi (1,603.65 km) |
| Portalegre to Scandicci | 1,007.41 mi (1,621.27 km) |
| Portalegre to Schio | 1,049.84 mi (1,689.56 km) |
| Portalegre to Sciacca | 1,114.72 mi (1,793.97 km) |
| Portalegre to Scicli | 1,212.89 mi (1,951.96 km) |
| Portalegre to Scordia | 1,212.14 mi (1,950.74 km) |
| Portalegre to Scorze | 1,081.68 mi (1,740.80 km) |
| Portalegre to Sedico | 1,092.63 mi (1,758.41 km) |
| Portalegre to Sedriano | 935.82 mi (1,506.06 km) |
| Portalegre to Segni | 1,083.30 mi (1,743.41 km) |
| Portalegre to Segrate | 950.85 mi (1,530.24 km) |
