| Portalegre to Spello | 1,072.63 mi (1,726.23 km) |
| Portalegre to Spilamberto | 1,011.07 mi (1,627.16 km) |
| Portalegre to Spilimbergo | 1,128.64 mi (1,816.37 km) |
| Portalegre to Spinea | 1,082.54 mi (1,742.18 km) |
| Portalegre to Spoleto | 1,071.50 mi (1,724.41 km) |
| Portalegre to Spoltore | 1,143.44 mi (1,840.20 km) |
| Portalegre to Spresiano | 1,092.44 mi (1,758.12 km) |
| Portalegre to Squinzano | 1,347.91 mi (2,169.24 km) |
| Portalegre to Statte | 1,302.65 mi (2,096.41 km) |
| Portalegre to Stezzano | 970.95 mi (1,562.60 km) |
| Portalegre to Strada | 1,011.42 mi (1,627.72 km) |
| Portalegre to Stradella | 941.47 mi (1,515.15 km) |
| Portalegre to Striano | 1,163.95 mi (1,873.20 km) |
| Portalegre to Subiaco | 1,088.28 mi (1,751.42 km) |
| Portalegre to Sulmona | 1,131.03 mi (1,820.21 km) |
