| Portalegre to Sangeorz-Bai | 1,691.93 mi (2,722.89 km) |
| Portalegre to Sannicolau Mare | 1,488.81 mi (2,396.00 km) |
| Portalegre to Santana | 1,533.61 mi (2,468.10 km) |
| Portalegre to Satu Mare | 1,613.84 mi (2,597.22 km) |
| Portalegre to Scobinti | 1,796.80 mi (2,891.68 km) |
| Portalegre to Scornicesti | 1,671.08 mi (2,689.34 km) |
| Portalegre to Sebes | 1,628.92 mi (2,621.50 km) |
| Portalegre to Seini | 1,631.44 mi (2,625.54 km) |
| Portalegre to Sfantu-Gheorghe | 1,734.75 mi (2,791.81 km) |
| Portalegre to Sibiu | 1,655.86 mi (2,664.84 km) |
| Portalegre to Sighetu Marmatiei | 1,661.26 mi (2,673.54 km) |
| Portalegre to Sighisoara | 1,688.76 mi (2,717.79 km) |
| Portalegre to Simeria | 1,601.41 mi (2,577.22 km) |
| Portalegre to Sinaia | 1,721.68 mi (2,770.78 km) |
| Portalegre to Slatina | 1,661.72 mi (2,674.28 km) |
