| Portsmouth to Sacile | 705.94 mi (1,136.10 km) |
| Portsmouth to Sala Consilina | 1,076.04 mi (1,731.72 km) |
| Portsmouth to Salemi | 1,126.01 mi (1,812.13 km) |
| Portsmouth to Salerno | 1,032.01 mi (1,660.86 km) |
| Portsmouth to Salo | 643.63 mi (1,035.81 km) |
| Portsmouth to Salsomaggiore Terme | 658.39 mi (1,059.58 km) |
| Portsmouth to Saluzzo | 582.45 mi (937.36 km) |
| Portsmouth to Salzano | 707.64 mi (1,138.84 km) |
| Portsmouth to Samarate | 578.04 mi (930.26 km) |
| Portsmouth to San Benedetto del Tronto | 888.56 mi (1,430.00 km) |
| Portsmouth to San Biagio di Callalta | 712.00 mi (1,145.85 km) |
| Portsmouth to San Bonifacio | 680.77 mi (1,095.59 km) |
| Portsmouth to San Casciano in Val di Pesa | 756.91 mi (1,218.13 km) |
| Portsmouth to San Cataldo | 1,180.85 mi (1,900.39 km) |
| Portsmouth to San Cesareo | 905.55 mi (1,457.35 km) |
