| Poughkeepsie to Des Plaines (Illinois) | 718.91 mi (1,156.98 km) |
| Poughkeepsie to Desert Hot Springs (California) | 2,361.61 mi (3,800.64 km) |
| Poughkeepsie to DeSoto (Texas) | 1,405.14 mi (2,261.35 km) |
| Poughkeepsie to Destin (Florida) | 1,047.02 mi (1,685.01 km) |
| Poughkeepsie to Destrehan (Louisiana) | 1,223.24 mi (1,968.61 km) |
| Poughkeepsie to Detroit (Michigan) | 473.30 mi (761.70 km) |
| Poughkeepsie to Diamond Bar (California) | 2,425.94 mi (3,904.17 km) |
| Poughkeepsie to Diamond Springs (California) | 2,454.27 mi (3,949.76 km) |
| Poughkeepsie to Dickinson (North Dakota) | 1,463.23 mi (2,354.84 km) |
| Poughkeepsie to Dickinson (Texas) | 1,451.62 mi (2,336.16 km) |
| Poughkeepsie to Dickson (Tennessee) | 819.88 mi (1,319.46 km) |
| Poughkeepsie to Difficult Run (Virginia) | 264.24 mi (425.25 km) |
| Poughkeepsie to Dinuba (California) | 2,435.07 mi (3,918.86 km) |
| Poughkeepsie to Discovery Bay (California) | 2,512.04 mi (4,042.75 km) |
| Poughkeepsie to Dix Hills (New York) | 68.67 mi (110.51 km) |
