| Poughkeepsie to Enterprise (Nevada) | 2,235.19 mi (3,597.20 km) |
| Poughkeepsie to Enumclaw (Washington) | 2,363.02 mi (3,802.91 km) |
| Poughkeepsie to Ephrata (Pennsylvania) | 157.65 mi (253.71 km) |
| Poughkeepsie to Erie (Colorado) | 1,621.12 mi (2,608.94 km) |
| Poughkeepsie to Erie (Pennsylvania) | 317.63 mi (511.17 km) |
| Poughkeepsie to Erlanger (Kentucky) | 590.92 mi (951.00 km) |
| Poughkeepsie to Escanaba (Michigan) | 713.61 mi (1,148.44 km) |
| Poughkeepsie to Escondido (California) | 2,414.10 mi (3,885.11 km) |
| Poughkeepsie to Española (New Mexico) | 1,763.04 mi (2,837.34 km) |
| Poughkeepsie to Essex (Maryland) | 211.92 mi (341.05 km) |
| Poughkeepsie to Essex Junction (Vermont) | 197.37 mi (317.64 km) |
| Poughkeepsie to Estelle (Louisiana) | 1,218.13 mi (1,960.39 km) |
| Poughkeepsie to Estero (Florida) | 1,145.83 mi (1,844.04 km) |
| Poughkeepsie to Euclid (Ohio) | 392.24 mi (631.24 km) |
| Poughkeepsie to Eufaula (Alabama) | 916.54 mi (1,475.03 km) |
