| Poughkeepsie to Santa Rosa (California) | 2,554.70 mi (4,111.40 km) |
| Poughkeepsie to Santaquin (Utah) | 1,967.50 mi (3,166.39 km) |
| Poughkeepsie to Santee (California) | 2,418.39 mi (3,892.02 km) |
| Poughkeepsie to Sapulpa (Oklahoma) | 1,252.23 mi (2,015.26 km) |
| Poughkeepsie to Saraland (Alabama) | 1,086.07 mi (1,747.87 km) |
| Poughkeepsie to Sarasota (Florida) | 1,105.28 mi (1,778.78 km) |
| Poughkeepsie to Sarasota Springs (Florida) | 1,105.47 mi (1,779.09 km) |
| Poughkeepsie to Saratoga (California) | 2,550.14 mi (4,104.05 km) |
| Poughkeepsie to Saratoga Springs (New York) | 95.11 mi (153.06 km) |
| Poughkeepsie to Saratoga Springs (Utah) | 1,966.70 mi (3,165.09 km) |
| Poughkeepsie to Sartell (Minnesota) | 1,047.15 mi (1,685.23 km) |
| Poughkeepsie to Satellite Beach (Florida) | 1,006.83 mi (1,620.34 km) |
| Poughkeepsie to Sauk Rapids (Minnesota) | 1,043.76 mi (1,679.77 km) |
| Poughkeepsie to Sault Ste. Marie (Michigan) | 614.36 mi (988.72 km) |
| Poughkeepsie to Savage (Minnesota) | 998.83 mi (1,607.45 km) |
