| Poughkeepsie to Silver Firs (Washington) | 2,363.77 mi (3,804.11 km) |
| Poughkeepsie to Silver Spring (Maryland) | 247.43 mi (398.20 km) |
| Poughkeepsie to Silver Springs Shores (Florida) | 980.48 mi (1,577.93 km) |
| Poughkeepsie to Silverdale (Washington) | 2,390.22 mi (3,846.68 km) |
| Poughkeepsie to Silverton (Oregon) | 2,428.14 mi (3,907.71 km) |
| Poughkeepsie to Simi Valley (California) | 2,466.02 mi (3,968.68 km) |
| Poughkeepsie to Simpsonville (South Carolina) | 660.00 mi (1,062.17 km) |
| Poughkeepsie to Sioux City (Iowa) | 1,149.93 mi (1,850.63 km) |
| Poughkeepsie to Sioux Falls (South Dakota) | 1,163.07 mi (1,871.78 km) |
| Poughkeepsie to Skokie (Illinois) | 710.66 mi (1,143.70 km) |
| Poughkeepsie to Sleepy Hollow (New York) | 41.63 mi (67.00 km) |
| Poughkeepsie to Slidell (Louisiana) | 1,182.76 mi (1,903.46 km) |
| Poughkeepsie to Smithfield (North Carolina) | 489.31 mi (787.47 km) |
| Poughkeepsie to Smithfield (Utah) | 1,937.34 mi (3,117.85 km) |
| Poughkeepsie to Smithville (Missouri) | 1,093.33 mi (1,759.54 km) |
