| Poughkeepsie to Southern Pines (North Carolina) | 538.12 mi (866.02 km) |
| Poughkeepsie to Southfield (Michigan) | 481.68 mi (775.19 km) |
| Poughkeepsie to Southgate (Michigan) | 478.17 mi (769.53 km) |
| Poughkeepsie to Southlake (Texas) | 1,405.95 mi (2,262.65 km) |
| Poughkeepsie to Spanaway (Washington) | 2,384.26 mi (3,837.10 km) |
| Poughkeepsie to Spanish Fork (Utah) | 1,957.06 mi (3,149.58 km) |
| Poughkeepsie to Spanish Lake (Missouri) | 880.67 mi (1,417.30 km) |
| Poughkeepsie to Spanish Springs (Nevada) | 2,373.05 mi (3,819.06 km) |
| Poughkeepsie to Sparks (Nevada) | 2,377.24 mi (3,825.81 km) |
| Poughkeepsie to Spartanburg (South Carolina) | 636.45 mi (1,024.27 km) |
| Poughkeepsie to Spearfish (South Dakota) | 1,512.08 mi (2,433.46 km) |
| Poughkeepsie to Speedway (Indiana) | 657.90 mi (1,058.80 km) |
| Poughkeepsie to Spencer (Iowa) | 1,084.67 mi (1,745.60 km) |
| Poughkeepsie to Spokane (Washington) | 2,147.75 mi (3,456.47 km) |
| Poughkeepsie to Spokane Valley (Washington) | 2,138.58 mi (3,441.72 km) |
