| Pueblo to Enterprise (Nevada) | 604.85 mi (973.42 km) |
| Pueblo to Enumclaw (Washington) | 1,072.50 mi (1,726.02 km) |
| Pueblo to Ephrata (Pennsylvania) | 1,520.90 mi (2,447.65 km) |
| Pueblo to Erie (Colorado) | 124.45 mi (200.28 km) |
| Pueblo to Erie (Pennsylvania) | 1,317.24 mi (2,119.89 km) |
| Pueblo to Erlanger (Kentucky) | 1,079.73 mi (1,737.66 km) |
| Pueblo to Escanaba (Michigan) | 1,034.07 mi (1,664.18 km) |
| Pueblo to Escondido (California) | 783.08 mi (1,260.25 km) |
| Pueblo to Española (New Mexico) | 175.91 mi (283.11 km) |
| Pueblo to Essex (Maryland) | 1,512.52 mi (2,434.17 km) |
| Pueblo to Essex Junction (Vermont) | 1,677.12 mi (2,699.06 km) |
| Pueblo to Estelle (Louisiana) | 1,012.21 mi (1,629.00 km) |
| Pueblo to Estero (Florida) | 1,556.42 mi (2,504.82 km) |
| Pueblo to Euclid (Ohio) | 1,240.92 mi (1,997.07 km) |
| Pueblo to Eufaula (Alabama) | 1,181.80 mi (1,901.92 km) |
