| Pueblo to Southern Pines (North Carolina) | 1,407.49 mi (2,265.13 km) |
| Pueblo to Southfield (Michigan) | 1,157.40 mi (1,862.66 km) |
| Pueblo to Southgate (Michigan) | 1,157.93 mi (1,863.50 km) |
| Pueblo to Southlake (Texas) | 556.89 mi (896.23 km) |
| Pueblo to Spanaway (Washington) | 1,087.05 mi (1,749.44 km) |
| Pueblo to Spanish Fork (Utah) | 397.17 mi (639.18 km) |
| Pueblo to Spanish Lake (Missouri) | 778.55 mi (1,252.96 km) |
| Pueblo to Spanish Springs (Nevada) | 813.64 mi (1,309.43 km) |
| Pueblo to Sparks (Nevada) | 815.95 mi (1,313.15 km) |
| Pueblo to Spartanburg (South Carolina) | 1,275.72 mi (2,053.08 km) |
| Pueblo to Spearfish (South Dakota) | 431.79 mi (694.89 km) |
| Pueblo to Speedway (Indiana) | 989.43 mi (1,592.33 km) |
| Pueblo to Spencer (Iowa) | 598.50 mi (963.20 km) |
| Pueblo to Spokane (Washington) | 915.17 mi (1,472.82 km) |
| Pueblo to Spokane Valley (Washington) | 907.97 mi (1,461.24 km) |
