| Pueblo to University Place (Washington) | 1,095.91 mi (1,763.70 km) |
| Pueblo to Upland (California) | 781.23 mi (1,257.27 km) |
| Pueblo to Upper Arlington (Ohio) | 1,157.74 mi (1,863.20 km) |
| Pueblo to Upper Grand Lagoon (Florida) | 1,211.48 mi (1,949.69 km) |
| Pueblo to Upper Montclair (New Jersey) | 1,621.53 mi (2,609.60 km) |
| Pueblo to Urbana (Illinois) | 886.83 mi (1,427.22 km) |
| Pueblo to Urbana (Maryland) | 1,464.64 mi (2,357.11 km) |
| Pueblo to Urbana (Ohio) | 1,121.53 mi (1,804.93 km) |
| Pueblo to Urbandale (Iowa) | 618.47 mi (995.34 km) |
| Pueblo to Utica (New York) | 1,566.80 mi (2,521.52 km) |
| Pueblo to Uvalde (Texas) | 684.20 mi (1,101.12 km) |
| Pueblo to Vacaville (California) | 939.53 mi (1,512.02 km) |
| Pueblo to Vadnais Heights (Minnesota) | 756.68 mi (1,217.76 km) |
| Pueblo to Vail (Arizona) | 551.49 mi (887.53 km) |
| Pueblo to Valdosta (Georgia) | 1,313.66 mi (2,114.13 km) |
