| Puerto de la Cruz to Sacile | 1,987.91 mi (3,199.23 km) |
| Puerto de la Cruz to Sala Consilina | 1,996.48 mi (3,213.03 km) |
| Puerto de la Cruz to Salemi | 1,809.06 mi (2,911.41 km) |
| Puerto de la Cruz to Salerno | 1,958.92 mi (3,152.58 km) |
| Puerto de la Cruz to Salo | 1,892.54 mi (3,045.74 km) |
| Puerto de la Cruz to Salsomaggiore Terme | 1,842.53 mi (2,965.27 km) |
| Puerto de la Cruz to Saluzzo | 1,731.38 mi (2,786.39 km) |
| Puerto de la Cruz to Salzano | 1,957.74 mi (3,150.67 km) |
| Puerto de la Cruz to Samarate | 1,820.43 mi (2,929.70 km) |
| Puerto de la Cruz to San Benedetto del Tronto | 1,965.11 mi (3,162.54 km) |
| Puerto de la Cruz to San Biagio di Callalta | 1,973.96 mi (3,176.79 km) |
| Puerto de la Cruz to San Bonifacio | 1,917.70 mi (3,086.24 km) |
| Puerto de la Cruz to San Casciano in Val di Pesa | 1,859.27 mi (2,992.21 km) |
| Puerto de la Cruz to San Cataldo | 1,867.94 mi (3,006.16 km) |
| Puerto de la Cruz to San Cesareo | 1,886.06 mi (3,035.31 km) |
