| Puerto de la Cruz to Savignano sul Rubicone | 1,926.37 mi (3,100.19 km) |
| Puerto de la Cruz to Savona | 1,761.09 mi (2,834.19 km) |
| Puerto de la Cruz to Scafati | 1,948.51 mi (3,135.82 km) |
| Puerto de la Cruz to Scalea | 1,997.14 mi (3,214.08 km) |
| Puerto de la Cruz to Scandiano | 1,865.90 mi (3,002.88 km) |
| Puerto de la Cruz to Scandicci | 1,862.32 mi (2,997.11 km) |
| Puerto de la Cruz to Schio | 1,930.98 mi (3,107.62 km) |
| Puerto de la Cruz to Sciacca | 1,820.16 mi (2,929.26 km) |
| Puerto de la Cruz to Scicli | 1,899.04 mi (3,056.20 km) |
| Puerto de la Cruz to Scordia | 1,912.59 mi (3,078.02 km) |
| Puerto de la Cruz to Scorze | 1,958.62 mi (3,152.10 km) |
| Puerto de la Cruz to Sedico | 1,975.79 mi (3,179.73 km) |
| Puerto de la Cruz to Sedriano | 1,823.13 mi (2,934.04 km) |
| Puerto de la Cruz to Segni | 1,893.46 mi (3,047.24 km) |
| Puerto de la Cruz to Segrate | 1,836.97 mi (2,956.32 km) |
