| Puerto de la Cruz to Spello | 1,909.10 mi (3,072.41 km) |
| Puerto de la Cruz to Spilamberto | 1,878.42 mi (3,023.02 km) |
| Puerto de la Cruz to Spilimbergo | 2,009.43 mi (3,233.87 km) |
| Puerto de la Cruz to Spinea | 1,958.36 mi (3,151.67 km) |
| Puerto de la Cruz to Spoleto | 1,903.72 mi (3,063.73 km) |
| Puerto de la Cruz to Spoltore | 1,965.57 mi (3,163.28 km) |
| Puerto de la Cruz to Spresiano | 1,971.39 mi (3,172.65 km) |
| Puerto de la Cruz to Squinzano | 2,122.45 mi (3,415.76 km) |
| Puerto de la Cruz to Statte | 2,080.89 mi (3,348.87 km) |
| Puerto de la Cruz to Stezzano | 1,857.51 mi (2,989.38 km) |
| Puerto de la Cruz to Strada | 1,863.04 mi (2,998.28 km) |
| Puerto de la Cruz to Stradella | 1,822.82 mi (2,933.54 km) |
| Puerto de la Cruz to Striano | 1,951.80 mi (3,141.12 km) |
| Puerto de la Cruz to Subiaco | 1,903.31 mi (3,063.08 km) |
| Puerto de la Cruz to Sulmona | 1,945.96 mi (3,131.71 km) |
