| Puerto de la Cruz to Sesimbra | 814.47 mi (1,310.77 km) |
| Puerto de la Cruz to Setubal | 825.37 mi (1,328.31 km) |
| Puerto de la Cruz to Sever do Vouga | 968.91 mi (1,559.31 km) |
| Puerto de la Cruz to Silves | 766.82 mi (1,234.07 km) |
| Puerto de la Cruz to Sines | 794.15 mi (1,278.06 km) |
| Puerto de la Cruz to Sintra | 826.62 mi (1,330.31 km) |
| Puerto de la Cruz to Sobrado de Paiva | 989.37 mi (1,592.24 km) |
| Puerto de la Cruz to Sobral de Monte Agraco | 846.17 mi (1,361.78 km) |
| Puerto de la Cruz to Soure | 921.30 mi (1,482.69 km) |
| Puerto de la Cruz to Tabua | 956.47 mi (1,539.28 km) |
| Puerto de la Cruz to Tavira | 792.09 mi (1,274.74 km) |
| Puerto de la Cruz to Tomar | 901.28 mi (1,450.47 km) |
| Puerto de la Cruz to Tondela | 964.02 mi (1,551.44 km) |
| Puerto de la Cruz to Torre de Moncorvo | 1,030.72 mi (1,658.78 km) |
| Puerto de la Cruz to Torres Novas | 890.17 mi (1,432.59 km) |
