| Rancho San Diego to Southern Pines (North Carolina) | 2,143.38 mi (3,449.43 km) |
| Rancho San Diego to Southfield (Michigan) | 1,945.27 mi (3,130.61 km) |
| Rancho San Diego to Southgate (Michigan) | 1,945.20 mi (3,130.50 km) |
| Rancho San Diego to Southlake (Texas) | 1,145.79 mi (1,843.97 km) |
| Rancho San Diego to Spanaway (Washington) | 1,031.84 mi (1,660.58 km) |
| Rancho San Diego to Spanish Fork (Utah) | 586.10 mi (943.24 km) |
| Rancho San Diego to Spanish Lake (Missouri) | 1,547.95 mi (2,491.19 km) |
| Rancho San Diego to Spanish Springs (Nevada) | 500.34 mi (805.22 km) |
| Rancho San Diego to Sparks (Nevada) | 495.71 mi (797.76 km) |
| Rancho San Diego to Spartanburg (South Carolina) | 2,003.45 mi (3,224.23 km) |
| Rancho San Diego to Spearfish (South Dakota) | 1,072.87 mi (1,726.62 km) |
| Rancho San Diego to Speedway (Indiana) | 1,766.43 mi (2,842.79 km) |
| Rancho San Diego to Spencer (Iowa) | 1,379.72 mi (2,220.45 km) |
| Rancho San Diego to Spokane (Washington) | 1,030.16 mi (1,657.89 km) |
| Rancho San Diego to Spokane Valley (Washington) | 1,029.64 mi (1,657.04 km) |
