| Rancho Santa Margarita to Denver (Colorado) | 821.11 mi (1,321.44 km) |
| Rancho Santa Margarita to Portland (Oregon) | 864.96 mi (1,392.03 km) |
| Rancho Santa Margarita to Seattle (Washington) | 997.33 mi (1,605.05 km) |
| Rancho Santa Margarita to Dallas (Texas) | 1,203.59 mi (1,936.99 km) |
| Rancho Santa Margarita to Houston (Texas) | 1,329.53 mi (2,139.67 km) |
| Rancho Santa Margarita to Minneapolis (Minnesota) | 1,509.48 mi (2,429.28 km) |
| Rancho Santa Margarita to St. Louis (Missouri) | 1,558.86 mi (2,508.74 km) |
| Rancho Santa Margarita to Chicago (Illinois) | 1,719.63 mi (2,767.48 km) |
| Rancho Santa Margarita to Atlanta (Georgia) | 1,898.78 mi (3,055.79 km) |
| Rancho Santa Margarita to Detroit (Michigan) | 1,957.53 mi (3,150.34 km) |
| Rancho Santa Margarita to Tampa (Florida) | 2,111.71 mi (3,398.47 km) |
| Rancho Santa Margarita to Washington (District of Columbia) | 2,270.97 mi (3,654.78 km) |
| Rancho Santa Margarita to Baltimore (Maryland) | 2,290.85 mi (3,686.77 km) |
| Rancho Santa Margarita to Miami (Florida) | 2,295.14 mi (3,693.67 km) |
| Rancho Santa Margarita to Philadelphia (Pennsylvania) | 2,366.88 mi (3,809.13 km) |
| Rancho Santa Margarita to Brooklyn (New York) | 2,426.96 mi (3,905.81 km) |
| Rancho Santa Margarita to New York (New York) | 2,428.10 mi (3,907.66 km) |
| Rancho Santa Margarita to Queens (New York) | 2,434.58 mi (3,918.08 km) |
| Rancho Santa Margarita to Riverside (California) | 24.19 mi (38.92 km) |
| Rancho Santa Margarita to Los Angeles (California) | 57.09 mi (91.87 km) |
| Rancho Santa Margarita to San Diego (California) | 61.79 mi (99.44 km) |
| Rancho Santa Margarita to Las Vegas (Nevada) | 223.09 mi (359.03 km) |
| Rancho Santa Margarita to Boston (Massachusetts) | 2,570.08 mi (4,136.14 km) |
| Rancho Santa Margarita to Phoenix (Arizona) | 317.06 mi (510.25 km) |
| Rancho Santa Margarita to San Francisco (California) | 393.75 mi (633.69 km) |
