| Republic to Sestu | 5,223.97 mi (8,407.17 km) |
| Republic to Settimo Torinese | 4,934.61 mi (7,941.48 km) |
| Republic to Seveso | 4,969.17 mi (7,997.10 km) |
| Republic to Sezze | 5,297.85 mi (8,526.06 km) |
| Republic to Siano | 5,394.05 mi (8,680.89 km) |
| Republic to Siena | 5,151.08 mi (8,289.86 km) |
| Republic to Signa | 5,122.56 mi (8,243.96 km) |
| Republic to Silea | 5,092.15 mi (8,195.02 km) |
| Republic to Silvi Paese | 5,294.96 mi (8,521.41 km) |
| Republic to Sinalunga | 5,171.45 mi (8,322.64 km) |
| Republic to Siniscola | 5,197.20 mi (8,364.08 km) |
| Republic to Sinnai | 5,228.62 mi (8,414.65 km) |
| Republic to Siracusa | 5,583.36 mi (8,985.55 km) |
| Republic to Solaro | 4,968.18 mi (7,995.51 km) |
| Republic to Soliera | 5,076.33 mi (8,169.57 km) |
