| San Sebastiano al Vesuvio to Southern Pines (North Carolina) | 4,861.12 mi (7,823.22 km) |
| San Sebastiano al Vesuvio to Southfield (Michigan) | 4,728.74 mi (7,610.17 km) |
| San Sebastiano al Vesuvio to Southgate (Michigan) | 4,737.60 mi (7,624.43 km) |
| San Sebastiano al Vesuvio to Southlake (Texas) | 5,730.94 mi (9,223.05 km) |
| San Sebastiano al Vesuvio to Spanaway (Washington) | 5,807.69 mi (9,346.57 km) |
| San Sebastiano al Vesuvio to Spanish Fork (Utah) | 5,897.13 mi (9,490.51 km) |
| San Sebastiano al Vesuvio to Spanish Lake (Missouri) | 5,172.22 mi (8,323.88 km) |
| San Sebastiano al Vesuvio to Spanish Springs (Nevada) | 6,169.38 mi (9,928.66 km) |
| San Sebastiano al Vesuvio to Sparks (Nevada) | 6,175.56 mi (9,938.60 km) |
| San Sebastiano al Vesuvio to Spartanburg (South Carolina) | 4,984.99 mi (8,022.57 km) |
| San Sebastiano al Vesuvio to Spearfish (South Dakota) | 5,407.87 mi (8,703.12 km) |
| San Sebastiano al Vesuvio to Speedway (Indiana) | 4,964.80 mi (7,990.07 km) |
| San Sebastiano al Vesuvio to Spencer (Iowa) | 5,166.08 mi (8,314.00 km) |
| San Sebastiano al Vesuvio to Spokane (Washington) | 5,647.37 mi (9,088.56 km) |
| San Sebastiano al Vesuvio to Spokane Valley (Washington) | 5,642.35 mi (9,080.49 km) |
