| Sanlucar la Mayor to Sacile | 1,128.50 mi (1,816.15 km) |
| Sanlucar la Mayor to Sala Consilina | 1,187.58 mi (1,911.23 km) |
| Sanlucar la Mayor to Salemi | 1,038.74 mi (1,671.69 km) |
| Sanlucar la Mayor to Salerno | 1,144.87 mi (1,842.49 km) |
| Sanlucar la Mayor to Salo | 1,032.31 mi (1,661.34 km) |
| Sanlucar la Mayor to Salsomaggiore Terme | 983.88 mi (1,583.41 km) |
| Sanlucar la Mayor to Saluzzo | 870.59 mi (1,401.08 km) |
| Sanlucar la Mayor to Salzano | 1,099.20 mi (1,768.99 km) |
| Sanlucar la Mayor to Samarate | 959.08 mi (1,543.49 km) |
| Sanlucar la Mayor to San Benedetto del Tronto | 1,124.62 mi (1,809.90 km) |
| Sanlucar la Mayor to San Biagio di Callalta | 1,115.23 mi (1,794.79 km) |
| Sanlucar la Mayor to San Bonifacio | 1,058.69 mi (1,703.79 km) |
| Sanlucar la Mayor to San Casciano in Val di Pesa | 1,008.16 mi (1,622.48 km) |
| Sanlucar la Mayor to San Cataldo | 1,105.24 mi (1,778.70 km) |
| Sanlucar la Mayor to San Cesareo | 1,054.33 mi (1,696.77 km) |
