| Sanlucar la Mayor to Sestu | 838.15 mi (1,348.88 km) |
| Sanlucar la Mayor to Settimo Torinese | 899.56 mi (1,447.71 km) |
| Sanlucar la Mayor to Seveso | 974.72 mi (1,568.66 km) |
| Sanlucar la Mayor to Sezze | 1,064.13 mi (1,712.56 km) |
| Sanlucar la Mayor to Siano | 1,142.18 mi (1,838.16 km) |
| Sanlucar la Mayor to Siena | 1,007.53 mi (1,621.47 km) |
| Sanlucar la Mayor to Signa | 1,007.09 mi (1,620.76 km) |
| Sanlucar la Mayor to Silea | 1,110.59 mi (1,787.32 km) |
| Sanlucar la Mayor to Silvi Paese | 1,130.24 mi (1,818.95 km) |
| Sanlucar la Mayor to Sinalunga | 1,024.69 mi (1,649.08 km) |
| Sanlucar la Mayor to Siniscola | 880.46 mi (1,416.96 km) |
| Sanlucar la Mayor to Sinnai | 844.11 mi (1,358.46 km) |
| Sanlucar la Mayor to Siracusa | 1,179.79 mi (1,898.69 km) |
| Sanlucar la Mayor to Solaro | 971.50 mi (1,563.48 km) |
| Sanlucar la Mayor to Soliera | 1,023.73 mi (1,647.53 km) |
