| Sanlucar la Mayor to Spello | 1,065.88 mi (1,715.37 km) |
| Sanlucar la Mayor to Spilamberto | 1,022.27 mi (1,645.19 km) |
| Sanlucar la Mayor to Spilimbergo | 1,149.95 mi (1,850.66 km) |
| Sanlucar la Mayor to Spinea | 1,100.00 mi (1,770.27 km) |
| Sanlucar la Mayor to Spoleto | 1,062.50 mi (1,709.94 km) |
| Sanlucar la Mayor to Spoltore | 1,130.10 mi (1,818.72 km) |
| Sanlucar la Mayor to Spresiano | 1,112.25 mi (1,790.00 km) |
| Sanlucar la Mayor to Squinzano | 1,316.45 mi (2,118.62 km) |
| Sanlucar la Mayor to Statte | 1,272.11 mi (2,047.27 km) |
| Sanlucar la Mayor to Stezzano | 996.56 mi (1,603.81 km) |
| Sanlucar la Mayor to Strada | 1,012.66 mi (1,629.72 km) |
| Sanlucar la Mayor to Stradella | 962.68 mi (1,549.28 km) |
| Sanlucar la Mayor to Striano | 1,135.62 mi (1,827.60 km) |
| Sanlucar la Mayor to Subiaco | 1,070.98 mi (1,723.58 km) |
| Sanlucar la Mayor to Sulmona | 1,114.14 mi (1,793.04 km) |
