| Sansepolcro to Settimo Torinese | 241.51 mi (388.67 km) |
| Sansepolcro to Seveso | 205.60 mi (330.88 km) |
| Sansepolcro to Sezze | 150.91 mi (242.86 km) |
| Sansepolcro to Siano | 231.83 mi (373.10 km) |
| Sansepolcro to Siena | 44.47 mi (71.56 km) |
| Sansepolcro to Signa | 54.10 mi (87.07 km) |
| Sansepolcro to Silea | 143.85 mi (231.50 km) |
| Sansepolcro to Silvi Paese | 122.22 mi (196.69 km) |
| Sansepolcro to Sinalunga | 32.25 mi (51.90 km) |
| Sansepolcro to Siniscola | 242.38 mi (390.07 km) |
| Sansepolcro to Sinnai | 332.16 mi (534.56 km) |
| Sansepolcro to Siracusa | 478.98 mi (770.84 km) |
| Sansepolcro to Solaro | 206.18 mi (331.81 km) |
| Sansepolcro to Soliera | 100.52 mi (161.77 km) |
| Sansepolcro to Solofra | 234.67 mi (377.66 km) |
