| Santa Clara to Enterprise (Nevada) | 384.92 mi (619.47 km) |
| Santa Clara to Enumclaw (Washington) | 679.69 mi (1,093.85 km) |
| Santa Clara to Ephrata (Pennsylvania) | 2,446.76 mi (3,937.67 km) |
| Santa Clara to Erie (Colorado) | 929.79 mi (1,496.36 km) |
| Santa Clara to Erie (Pennsylvania) | 2,227.31 mi (3,584.51 km) |
| Santa Clara to Erlanger (Kentucky) | 2,018.97 mi (3,249.22 km) |
| Santa Clara to Escanaba (Michigan) | 1,876.97 mi (3,020.69 km) |
| Santa Clara to Escondido (California) | 402.01 mi (646.98 km) |
| Santa Clara to Española (New Mexico) | 884.90 mi (1,424.11 km) |
| Santa Clara to Essex (Maryland) | 2,444.70 mi (3,934.36 km) |
| Santa Clara to Essex Junction (Vermont) | 2,558.27 mi (4,117.14 km) |
| Santa Clara to Estelle (Louisiana) | 1,895.87 mi (3,051.11 km) |
| Santa Clara to Estero (Florida) | 2,454.01 mi (3,949.35 km) |
| Santa Clara to Euclid (Ohio) | 2,156.96 mi (3,471.28 km) |
| Santa Clara to Eufaula (Alabama) | 2,112.98 mi (3,400.51 km) |
