| Santa Comba to Sestu | 964.37 mi (1,552.00 km) |
| Santa Comba to Settimo Torinese | 833.99 mi (1,342.18 km) |
| Santa Comba to Seveso | 903.12 mi (1,453.44 km) |
| Santa Comba to Sezze | 1,120.58 mi (1,803.39 km) |
| Santa Comba to Siano | 1,214.38 mi (1,954.35 km) |
| Santa Comba to Siena | 1,012.75 mi (1,629.86 km) |
| Santa Comba to Signa | 998.46 mi (1,606.86 km) |
| Santa Comba to Silea | 1,055.44 mi (1,698.57 km) |
| Santa Comba to Silvi Paese | 1,159.48 mi (1,866.00 km) |
| Santa Comba to Sinalunga | 1,033.60 mi (1,663.42 km) |
| Santa Comba to Siniscola | 966.35 mi (1,555.18 km) |
| Santa Comba to Sinnai | 969.83 mi (1,560.80 km) |
| Santa Comba to Siracusa | 1,334.27 mi (2,147.30 km) |
| Santa Comba to Solaro | 900.38 mi (1,449.02 km) |
| Santa Comba to Soliera | 987.42 mi (1,589.09 km) |
