| Santa Cruz de la Palma to Sacile | 2,027.17 mi (3,262.41 km) |
| Santa Cruz de la Palma to Sala Consilina | 2,048.74 mi (3,297.12 km) |
| Santa Cruz de la Palma to Salemi | 1,865.37 mi (3,002.03 km) |
| Santa Cruz de la Palma to Salerno | 2,010.32 mi (3,235.29 km) |
| Santa Cruz de la Palma to Salo | 1,931.05 mi (3,107.73 km) |
| Santa Cruz de la Palma to Salsomaggiore Terme | 1,882.31 mi (3,029.28 km) |
| Santa Cruz de la Palma to Saluzzo | 1,769.28 mi (2,847.39 km) |
| Santa Cruz de la Palma to Salzano | 1,997.62 mi (3,214.86 km) |
| Santa Cruz de la Palma to Samarate | 1,857.38 mi (2,989.17 km) |
| Santa Cruz de la Palma to San Benedetto del Tronto | 2,011.52 mi (3,237.23 km) |
| Santa Cruz de la Palma to San Biagio di Callalta | 2,013.72 mi (3,240.77 km) |
| Santa Cruz de la Palma to San Bonifacio | 1,957.24 mi (3,149.88 km) |
| Santa Cruz de la Palma to San Casciano in Val di Pesa | 1,902.51 mi (3,061.80 km) |
| Santa Cruz de la Palma to San Cataldo | 1,925.22 mi (3,098.35 km) |
| Santa Cruz de la Palma to San Cesareo | 1,934.23 mi (3,112.85 km) |
