| Santa Cruz de la Palma to Savignano sul Rubicone | 1,969.51 mi (3,169.62 km) |
| Santa Cruz de la Palma to Savona | 1,800.70 mi (2,897.95 km) |
| Santa Cruz de la Palma to Scafati | 1,999.66 mi (3,218.14 km) |
| Santa Cruz de la Palma to Scalea | 2,050.57 mi (3,300.07 km) |
| Santa Cruz de la Palma to Scandiano | 1,906.74 mi (3,068.60 km) |
| Santa Cruz de la Palma to Scandicci | 1,905.35 mi (3,066.36 km) |
| Santa Cruz de la Palma to Schio | 1,969.92 mi (3,170.28 km) |
| Santa Cruz de la Palma to Sciacca | 1,877.15 mi (3,020.98 km) |
| Santa Cruz de la Palma to Scicli | 1,957.74 mi (3,150.68 km) |
| Santa Cruz de la Palma to Scordia | 1,970.42 mi (3,171.08 km) |
| Santa Cruz de la Palma to Scorze | 1,998.42 mi (3,216.15 km) |
| Santa Cruz de la Palma to Sedico | 2,014.44 mi (3,241.92 km) |
| Santa Cruz de la Palma to Sedriano | 1,860.54 mi (2,994.25 km) |
| Santa Cruz de la Palma to Segni | 1,942.03 mi (3,125.40 km) |
| Santa Cruz de la Palma to Segrate | 1,874.67 mi (3,016.98 km) |
